However, early studies revealed that IL-4 needed to be neutralized within the first few days of infection in order for long-term clearance of infection in susceptible mice [38] suggesting that, once established, the IL-4 response dominates immunity to Leishmania. Indeed, analysis of the L. major infected dermis using a multi-parameter FACS panel and infection of IL-4-GFP reporter mice (4get) [33] revealed GFP+ immune cells with IL-4 potential in both adaptive and innate compartments. This evidence concerns the gene IL4 and infection.