In the past years, numerous genetic association studies have explored the role of TLR9 gene polymorphisms in various cancers, including bladder cancer [14], prostate cancer [15], acute lymphoblastic leukemia (ALL) [16], hepatocellular carcinoma (HCC) [17], gastric cancer [18]–[20], cervical cancer [2], [13], [21], Hodgkin’s lymphoma [22], breast cancer [23], burkitt’s lymphoma [24], non-Hodgkin lymphoma [25], endometrial cancer [26], esophageal cancer [20] and lymphoma [27]. This evidence concerns the gene TLR9 and hepatocellular carcinoma.