PDGFRA and neoplasm: MGMT promoter methylation was significantly less frequent in tumours with all three genes amplified (6/19, 31.6%) than the cohort as a whole (154/247, 62.3%, p = 0.026, Fishers exact test); by contrast tumours amplified for PDGFRA alone had significantly more MGMT promoter methylation (7/9, 77.8%, p = 0.042, Fishers exact test).