AIH pathogenesis are more complex than the traditional dichotomous Th1/Th2 paradigm, where STAT4 represents a transcription factor that induces IL-12, IL-23 and type 1 IFN-mediated signals to Th1 and Th17 differentiation, monocyte activation and interferon-γ production [39]. This evidence concerns the gene STAT4 and autoimmune hepatitis.