This is particularly interesting from a therapeutic point of view since a Wnt-5a-derived peptide has been shown to reduce distant metastasis by 70–90% in a breast cancer mouse model [17], suggesting that reconstitution of Wnt-5a signaling in Wnt-5a negative tumors is a promising novel targeted approach to prevent breast cancer metastases. Here, WNT5A is linked to breast carcinoma.