SOCS5 and neoplasm: More recently, epigenetic silencing of SOCS5 expression has been shown to correlate inversely with EGF-R expression in aggressive hepatocarcinoma [9], while down-regulation of SOCS5 expression by tumor-derived miR-9 results in enhanced JAK1/2 and STAT1/3 phosphorylation in endothelial cells [10].