Several studies were conducted to provide scientific basis on the extensive usage of G. cambogia and G. atroviridis associated with high-fat diet- (HFD-) induced obesity where dyslipidemia, fatty liver, insulin resistance, and hyperleptinemia were acquired along with the overexpression of leptin, TNF-α, resistin, PPARγ2, C/EBPα, and SREBP1c genes in epididymal adipose tissue. The gene discussed is LEP; the disease is obesity disorder.