PRRT2 and chronic obstructive pulmonary disease: Since the sensitivity of C-fibres to stimulation via the vanilloid receptor is enhanced by prostaglandins and by activation of protein kinase C (PKC) inside the C-fibres (533, 534), it will probably also be useful for COPD patients if the diet can be modified so that the rate of prostaglandin production and the degree of oxidative stress-mediated or diacylglycerol-induced activation of PKC inside the C-fibres also can be minimized – for reducing glucocorticoid production, tachycardia and sensation of respiratory distress.