We found that there is trend between interaction between APOE4 and p.E318G with episodic memory decline (p = 0.08).Furthermore, the significant effect of APOE ε4 allele on episodic memory decline (p = 1.7×10−16, Beta = −0.06) was modified by the presence of p.E318G (p = 0.14, Beta = −0.16).However, these interactions showed the predicted direction of effects for these phenotypes based on the results of the biomarker data: In the presence of at least one APOE-ε4 allele, p.E318G is associated with more Aβ plaques, faster cognitive decline and higher risk for AD. Here, APOE is linked to Alzheimer disease.