In this dataset, the association of p.E318G with AD case-control status in the presence of at least one APOE ε4 allele (OR = 10.3, 95% CI = 4.1–25.5, p = 4.1×10−8) was double the risk for AD in the presence of APOE ε4 alone (OR = 4.1, 95% CI = 3.5–4.8, p = 1.1×10−79). The gene discussed is APOE; the disease is Alzheimer disease.