GAB2 and Alzheimer disease: There are several reports of variants that modify the risk of AD in APOE ε4 carriers such as α-1-antichymotrypsin (ACT) gene (APOE ε4/ACT, [OR = 6.4, non 95% CI reported]) [54], Cholesteryl ester transfer protein (CETP) gene (APOE ε4/CETP [–629] C allele [OR 7.12, non 95% CI reported]) [55], GRB-associated binding protein 2 (GAB2) gene (APOE ε4/rs2373115 genotype GG [OR = 2.36, 95% CI 1.55–3.58]) [56], CUG triplet repeat, and RNA binding protein 2 (CUGBP2) gene (APOE ε4/ε4/rs62209 [OR = 1.75, 95% CI 1.27–2.41]) [57].