Moreover, we also found that in the presence of at least one APOE ε4 allele, p.E318G is associated with more Aβ plaques and faster cognitive decline, as recently reported for a low frequency variant in complement receptor 1 (CR1) [58] In addition, p.E318G has previously associated with lower cognitive performance, which support our findings of cognitive decline [45]. This evidence concerns the gene CR1 and Mental deterioration.