APOE and Alzheimer disease: In fact, we found that individuals who are APOE ε4 heterozygous and also carry the p.E318G variant are at similar AD risk (OR = 10.7, 95% CI = 4.7–24.6, p = 2.5×10−10) as APOE ε4 homozygous (OR = 9.9, 95% CI = 7.2.9–13.6, p = 5.5×10−76) and are at double the AD risk compared to APOE ε4 heterozygous that are not carrying p.E318G (OR = 3.9, 95% CI = 3.4–4.4, p = 2.8×10−106) (Table 6, Figure 2C).