In the joint-analysis of these two independent series (5,161 individuals), the risk of developing AD in the p.E318G/APOE ε4 carriers (OR = 10.1, 95% CI = 4.8–20.9, p = 9.0×10−12) is two-fold the AD risk of those that carry APOE ε4 allele alone (OR = 4.4, 95% CI = 3.9–5.0, p = 6.8×10−139) (Table 5). This evidence concerns the gene APOE and Alzheimer disease.