The macaques with the restrictive TRIM5TFP/TFP (Rh447) and TRIM5TFP/CypA (Rh458 and Rh063) genotypes had much lower plasma viral loads than the macaque with the permissive TRIM5Q/Q genotype (Rh444) during the acute stage of infection (Fig. 1). The gene discussed is TRIM39; the disease is infection.