NOTCH1 and glioblastoma: The role of Notch1-mediated signaling pathway in maintenance of neural stem cells, which contributes to growth and progression of glioblastomas, is essential, and it has been shown that Notch1 receptor promotes survival of glioblastoma cells by regulation of the anti-apoptotic Mcl-1 protein, which is mediated by the induction of EGFR (Fassl et al. 2012; Wang et al. 2010).