Remarkably, the genetic or pharmacological inhibition of p300 activity [the latter obtained by using Lys-CoA (10), a bi-substrate p300 inhibitor] led to growth inhibition, downregulation of cyclin E and activation of the senescence-associated acidic β-galactosidase in human melanocytes and melanoma cells, whose proliferation often occurs in elderly people [105]. Here, EP300 is linked to melanoma.