AKT1 and malignant colon neoplasm: Zheng et al. [7] demonstrated that Phx-3 inhibited the phosphorylation of Akt in human lung adenocarcinoma cell line A549 cells, suggesting that Phx-3 strongly suppresses Akt signaling in cancer cells, though it is not clear whether Phx-3 inhibits Akt signaling in gastric and colon cancer cells, therefore being still hypothetical.