CXXC5 and acute myeloid leukemia: In vitro cultured primary AML cells show spontaneous or stress-induced apoptosis that varies considerably between patients [9, 10]; this was also true both for the AML cells with low (median viability 22.5%, range 1.1-66.6%) and high (median viability 44.2%, range 9.6-56.2%) RINF expression.