The RINF gene localizes to the 5q31.2 chromosomal region that can be involved in chromosomal abnormalities associated with various myeloid malignancies, including the low-risk 5q-variant of human myelodysplastic syndromes (MDS) [1, 2] and the high-risk del5 and −5 abnormalities in human acute myeloid leukemia (AML) [3]. The gene discussed is CXXC5; the disease is acute myeloid leukemia.