In contrast, for AML cells with high RINF expression, the viability after culture in medium alone was higher and lenalidomide caused a statistically significant and dose-dependent further decrease in viability (lenalidomide 0.1 μM, no significant effect; lenalidomide 0.5 μM, median viability 31.6%, range 7.0-57.3%, p=0.0098; lenalidomide 1.0 μM, median viability 31.6, range 6.8-50.8; p=0.0078) compared with the corresponding drug-free cultures (median viability 44,2%, see above). The gene discussed is CXXC5; the disease is acute myeloid leukemia.