Examination of molecular changes in astrocytes in vivo has been traditionally difficult; however, recent development of an array of astrocyte reporter mice (BAC GLT1 eGFP [103], BAC ALDH1L1 eGFP [55], EAAT2 tdTomato [104]) has allowed rapid isolation of in vivo astrocytes from mouse models of neurodevelopmental disorders through fluorescence activated cell sorting (FACS) and subsequent genome-wide transcriptional profiling. Here, SLC1A2 is linked to neurodevelopmental disorder.