Our experimental study showed that ET-1 promotes the expression of functional CXCR4 in non-metastatic human NPC 6-10B cells and metastatic 5-8F cells and increases the migration ability of these cells through the PI3K/AKT and MAPK/ERK1/2 pathways. This evidence concerns the gene CXCR4 and nasopharyngeal carcinoma.