EGFR and malignant colon neoplasm: Alternatively, it has been known for some time now that a high vascular density increases the likelihood that tumor cells will enter the systemic circulation and reach distal organs of metastasis [58], and we found that the activation of autocrine and paracrine TGFα/EGFR signaling networks affects the tumor microenvironment in colon cancer and determines its impact on the formation of metastases.