We have recently shown that ApoE in an AD-associated, isoform-specific manner impairs ApoE receptor recycling at central synapses (Chen et al., 2010b) and that this impairs the ability of ApoE receptor-dependent signals to prevent β-amyloid induced synaptic suppression (Durakoglugil et al., 2009). The gene discussed is APOE; the disease is Alzheimer disease.