Our finding is consistent with previous observations, e.g., ectopic expression of hTERT in HMECs resulted in reduced basal level of active p53 (Belivaeu et al., 2007), while p53 deficient RKO colorectal cancer cells were four times more sensitive to paclitaxel compared to wild type RKO cells (Rakovitch et al., 1999). This evidence concerns the gene TP53 and colorectal cancer.