While 87% of mice immunized with rMVA developed severe symptoms of ECTV infection, including necrotic tails, swollen and necrotic paws, and skin lesions, and either died or had to be euthanized, only 47% of the rMVA-CD40L immunized mice developed infection symptoms during an observation period of 100 days (Figure 11B). This evidence concerns the gene CD40LG and infection.