Conversely, it could be envisaged that, in the tumor context, the low levels of IFN-γ derived from Tconv, NK, and CD8 cells, and the paucity of IL-12 production by tumor-associated APCs, may concur to induce a pool of Treg expressing T-bet but not secreting IFN-γ, thus specialized in suppressing anti-tumor type-1 immunity. The gene discussed is CD8A; the disease is neoplasm.