One study has directly addressed the issue of induced Treg functional specialization in tumors, by generating in vitro tumor-specific iTreg and co-culturing these cells, or tTreg as control, with NK cells: these authors found that iTreg and tTreg equally suppressed IL-2-induced NK activation, but only iTreg were endowed with the surprising ability not to suppress, but to enhance, NK cytotoxicity induced by tumor target cell contact (89). The gene discussed is IL2; the disease is neoplasm.