IDO1 and neoplasm: Other authors have shown that tTreg may dominate pTreg not only quantitatively but also qualitatively, in terms of suppressive function: indeed, IDO+ plasmacytoid dendritic cells, derived from mouse tumor-draining lymph nodes, were capable to induce Foxp3+ pTreg at very high levels but were unable to activate the suppressive function of these cells to an extent comparable to tTreg (72).