FOXP3 and neoplasm: In epithelial ovarian cancer, a malignancy associated to chronic inflammation, Tconv were found to secrete high levels of IL-17 (and other cytokines) when cultured ex vivo with IL-2; under similar conditions, tumor-infiltrating Treg were prone to FOXP3 downregulation, attenuation of suppressive function, and prompt IL-17 production (148).