IGHE and atopic eczema: In this study we demonstrated for the first time that epidermal keratinocyte-derived activin protects from antigen-specific T-cell immune response in an epicutaneous sensitization murine model, because: (1) It inhibited Th2-polarization after antigen-induced allergic dermatitis, (2) It hampered IgE and antigen-specific IgE production in mouse serum, and (3) It led to decrease of γδ T-cell population in injured skin.