Neuroinflammation, endothelial activation, endothelial cell hyperplasia, the attachment of white blood cells to the endothelial damaged walls with the reduction of the lumen vessel, high plasmatic concentrations of endothelin-1, and the breakdown of the BBB clearly contribute to cognitive impairment and the pathogenesis of neurodegenerative states (Jian et al., 2012; Roher et al., 2012). Here, EDN1 is linked to Cognitive impairment.