NFKB1 and Alzheimer disease: In AD these five up-regulated miRNAs appear to play important roles in the down-regulation of brain gene expression normally involved in the brain's neurotrophic support, synaptogenesis, the innate-immune response, NF-kB-mediated inflammatory signaling and amyloidogenesis (Cui et al., 2005; Sethi and Lukiw, 2009; Lukiw, 2012a,b; Zhao et al., 2013).