Selective unilateral renal D2R down-regulation in mice, in the absence of elevated blood pressure, reproduced the alterations in inflammatory factors and renal injury observed in D2R−/− mice, increasing the expression of several pro-inflammatory cytokines such as, TNFα, MCP-1, and MCP-2, suggesting that D2R plays a protective role against the development of renal inflammation [122]. The gene discussed is DRD2; the disease is inflammatory response.