EZH2 and plasma cell myeloma: As inhibition of EZH2 and H3K27me3 may affect clonogenicity and differentiation in normal stem cells and the GEP and western blot results implicated a central role for PRC2 proteins in the self-renewal of clonogenic myeloma cells, we wanted to examine whether DZNep, exerted a differential effect between CD138− and CD138+ populations.