Now a similar picture appears to evolve with respect to the role of YAP in colon cancer, since Camargo and colleagues found that YAP is silenced in a subset of highly aggressive and undifferentiated human colorectal carcinomas[118], while other studies suggest that YAP functions as a proto-oncoprotein in the colon[3]. This evidence concerns the gene YAP1 and malignant colon neoplasm.