Mst1/Mst2 deficient intestines develop colonic adenomas, and unlike the polyps described in the Sav1-deficient colon [56], the polypoid lesions in the Mst1/Mst2-deficient colon do not exhibit a sawtooth/serrated architecture but hyperproliferative adenoma which might result from an activation of β-catenin and/or the inactivation of the Hippo signaling pathway in these lesions [52,57]. The gene discussed is MST1; the disease is colon adenoma.