Mst1/2 intestinal DKO mice (Mst1−/−Mst2fl/fl-villin-Cre) with ablation of both Mst1 and Mst2 in intestinal compartment are born normal at birth, however they develop colonic adenomas within 3 months old and can only survive for about 13 weeks (median age) accompanied by severe wasting. Here, STK3 is linked to colon adenoma.