Collectively the data show significant and progressive increases in plasma IL-1β, IL-6, IL-10, IL-12p40, IL-13 and TNFα during progression to splenomegaly, suggesting that, as in HIV patients developing lymphoma [27,28], these changes are prognostic for the development of lymphadenopathy and splenomegaly in HIV Tg mice. The gene discussed is TNF; the disease is Splenomegaly.