TNF and cerebral malaria: Considering that the pro-inflammatory environment, and particularly infiltrating immune cells, contribute to the detrimental effects of cerebral malaria on neurons, including apoptosis in sensible neuronal populations[12,14,42], through extrinsic mediators of apoptosis such as TNF and NOS[12,43,44], we have addressed the effect of A. indica extract on these inflammatory triggers of apoptosis in P. berghei-infected mice.