GRK2 and myocardial infarction: In summary, the present study reports that cardiac GRK2 inhibition with βARKct in vivo is absolutely essential for the cardiac β2AR subtype’s pro-contractile function, all the while preserving and augmenting this receptor’s beneficial anti-apoptotic/pro-survival and pro-infarct healing signaling pathways post-MI, early on after the cardiac insult.