We utilized data from 994 non-Hispanic white asthma patients to measure the association of single nucleotide polymorphisms (SNPs) with severity of AHR and found that the strongest associations were at variants in two genes: ArfGAP with FG repeats 1 (AGFG1) and integrin, beta 5 (ITGB5). The gene discussed is AGFG1; the disease is asthma.