In this in vitro study performed in a human neuroblastoma SH-SY5Y cell line we assessed the effects of an acute exposure to rotenone, an inhibitor of the mitochondrial complex I activity able to reproduce the mitochondrial dysfunction typical of PD, on the expression of 2 critical protein associated to PD, alpha-synuclein, and MEF2D. Here, SNCA is linked to Parkinson disease.