Dectin-1 deficient mice are more susceptible to fungal infection when compared to control group, as demonstrated in a study where the deficient mice showed an impaired production of inflammatory cytokines and chemokines such as IL-1β, TNF-α, CCL3, CCL4, and CXCL1, leading to insufficient lung neutrophils recruitment and reactive oxygen species (ROS) production besides uncontrolled growth of A. fumigatus in lungs. The gene discussed is IL1B; the disease is fungal infectious disease.