This paper presents the influence of interactions between different genotypes (MnSOD Ala −9Val, ECSOD Arg213Gly, CAT −262C > T, GSTT1-null, GSTM1-null, GSTP1 Ile105Val, and Ala114Val and iNOS (CCTTT)n), between genotypes and smoking, and between genotypes and cumulative asbestos exposure on the risk of developing asbestosis. This evidence concerns the gene SOD2 and asbestosis.