There is one study about migraine and VDR polymorphisms; Schürks et al. evaluated the association between 77 polymorphisms and migraine and demonstrated that VDR polymorphisms FokI and BsmI are not associated with migraine while TNF, CCR2, TGFB, NOS3, and IL9 polymorphisms can affect the susceptibility of having migraine [38]. This evidence concerns the gene NOS3 and migraine disorder.