Discovered interactions that affect AD risk include (1) IL-6 and IL-10 discovered by Infante et al. [193] and replicated by Combarros et al. [184]; (2) GSTM3 and the HHEX/IDE/KIF11 locus discovered by Bullock et al. [185]; (3) HMGCR and ABCA1 discovered by Rodríguez-Rodríguez et al. [186]; and TF and HFE first reported by Robson et al. [194] and replicated by Kauwe et al. [187]. This evidence concerns the gene IL6 and Alzheimer disease.