Aberrant expression of the Bmi-1 in this tumors would change the composition of the PcG complex to proliferation cell cycle by transcription repressor of some genes such as p16Ink4A and p19Arf involved in tumor suppression, resulting in oncogenic effects, because the amounts of the Bmi-1 in the PcG complex determine its biochemical and biologic functions [27]. The gene discussed is CDKN2A; the disease is neoplasm.