Characterized by a progressive taupathy and also marked by TAR DNA-binding protein-43 (TDP-43) proteinopathy, CTE has only been found in individuals with a history of repeated brain trauma (Gavett et al. 2011; McKee et al. 2009; McKee et al. 2010; Stern et al. 2011). This evidence concerns the gene TARDBP and proteostasis deficiencies.