In recent years research to investigate other neurodegenerative diseases, like AD, has been moving to integrate clinical (e.g., neuropsychological tests), biological (e.g., cerebrospinal fluid), anatomical (e.g., neuroimaging), and genetic information (e.g., APOE genotype) for the purposes of differential diagnosis, prevention, and treatment. This evidence concerns the gene APOE and neurodegenerative disease.