In human SCC samples, TGF-β was overexpressed either suprabasally or throughout the tumor epithelia, including basal proliferative cells [248] suggesting that TGF-β is overexpressed in human SCC similar to its mouse counterpart skin carcinogenesis model, where it has been demonstrated that TGF-β promotes metastasis in the late stage [223]. The gene discussed is TGFB1; the disease is neoplasm.