FOS and malignant colon neoplasm: In colon cancer, constitutive and PMA-inducible expression of the gene requires AP-1 consensus motif at −190/−171, which binds Jun-D, c-Jun, c-Fos, and Fra-1 transcription factors and mediates the transactivation of uPAR promoter through ERK and JNK MAPK pathways [107, 108].