SRY and gonadoblastoma: So, analysis of SRY gene should be offered to all TS patients because of (1) increased risk of gonadoblastoma [10], (2) possibility of “low level hidden” mosaicism for a Y chromosome positive cell line in the gonads, variable ages of expression [23], (3) high malignancy potential of gonadoblastoma, and (4) necessity of timely referral for gonadectomy.