This frequency among gastric cancer was reported 46% in the study of Dr. Yong-Ning Zhou et al. in china, 3, 58% in the study by Dr. Chan et al. in Hong Kong 5, and 82% in the study of Dr. PabloGuzman et al.(8) These differences may be related to the method of mutation assessment (E-cadherin expression by IHC or E-cadherin gene methylation). The gene discussed is CDH1; the disease is gastric cancer.