More evidence further explores the critical role of microglia in stroke progression, because the experimental and postmortem studies reveal the presence of activated microglia in the brain of stroke patients [36, 37] and microglia are clarified as the major cell population that leads to NF-κB-dependent upregulation of proinflammatory molecules, such as TNF-α and IL-1β during stroke. This evidence concerns the gene NFKB1 and stroke disorder.