Furthermore, deletion of cytoplasmic copper/zinc superoxide dismutase (Cu-Zn-SOD, SOD1) in Tg2576 APP-overexpressing AD mouse model was found to increase Abeta oligomerization while accelerating the loss of spatial learning and memory as compared with control AD mice, suggesting a possible role of oxidative damage in Abeta oligomerization [45]. Here, APP is linked to Alzheimer disease.