Studies have shown that metal transporters such as Zn transporters and divalent metal transporter 1 (DMT1) are increased in the cortex and hippocampus of APP/PS1 transgenic mice; and similar to transition metals, these metal transporters are colocalized with Abeta in senile plaques in the cortex of AD brains [103, 106, 107]. This evidence concerns the gene APP and Alzheimer disease.