In SH-SY5Y neuroblastoma cells overexpressing APP or APP mutant, it was found that the upregulation of UCP2 and UCP4 protein levels in response to the exposure of superoxide was abrogated; although the mechanisms are unclear, it suggests that Abeta accumulation may lead to irreversible cellular alterations that render the cell more susceptible to oxidative stress [82]. The gene discussed is APP; the disease is neuroblastoma.