CREB1 and early-onset autosomal dominant Alzheimer disease: Similarly, EGb 761 restored impaired phosphorylation of CREB and brain-derived neurotrophic factor (BDNF) expression in β-amyloid-expressing neuroblastoma cells enhancing hippocampal neurogenesis and phosphorylation of CREB in a transgenic mouse model of Alzheimer's disease (AD) [117, 118].