It also increased the activity of glutathione peroxidase in nerves, depressed the activation of aldose reductase in erythrocytes, decreased the accumulation of advanced glycation end products in both nerves and erythrocytes, and elevated Na+, K+-ATPase activity in both the nerves and erythrocytes of diabetic rats, so it is considered to be protective against the progression of peripheral neuropathy [163]. Here, AKR1B1 is linked to peripheral neuropathy.