In the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP-) intoxicated mouse model of PD, adoptive transfer of CD3-activated CD25+CD4+ Tregs alleviated microglial-mediated inflammation and promoted expression of astrocyte-derived brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor, thus conferring neuroprotective effects [70]. Here, CD4 is linked to Parkinson disease.