Another prospective study in 46 consecutive patients with acute stroke, however, reported that increased apoptosis correlated with a decline in FoxP3+CD25+CD4+ Tregs and other types of immune cells (e.g., Th, CTL, and B cells) after stroke, but decreased FoxP3+CD25+CD4+ Tregs did not show any correlation with the development of infections or stroke outcomes [78]. This evidence concerns the gene CD4 and stroke disorder.