Downregulation of DNMT1 in CD4+ T cells contributes to lupus autoreactivity by inducing T cell DNA hypomethylation; this results in the overexpression of autoimmunity-associated genes including lymphocyte function-associated antigen 1 (LFA-1 or CD11a) and CD70 [89]. This evidence concerns the gene ITGAL and systemic lupus erythematosus.