Intriguingly, genomewide association studies have identified an association between SLE risk and a functional variant of ETS1. The researchers observed additive effects of the risk alleles of miR-146a and ETS1, which suggests that individuals with 2 or more of these alleles are at a greater risk of developing SLE than those carrying only one allele [63]. The gene discussed is ETS1; the disease is systemic lupus erythematosus.