One of the mutations found in PCa patients consists of a single nucleotide change that creates a binding site for the splicing factor SRSF5 (SRp40) and enhances splicing of three alternative mRNA variants encoding for truncated KLF proteins, named KLF6-SV1, SV2, and SV3 [16]. The gene discussed is KLF6; the disease is posterior cortical atrophy.