TP53 and gastric cancer: Among other tumor suppressor genes inactivated by DNA methylation, Reprimo (RPRM), a downstream mediator of p53-induced G2 cell cycle arrest [47], has been recently associated with more aggressive H. pylori strains (cag-positive, vacA s1 m1, and EPIYA polymorphisms) in Colombian residents from areas with high incidence of gastric cancer [48].